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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Neferine, Vitamin D3
Phytochemical Name Neferine (PubChem CID: 159654 )
Anticancer drug Name Vitamin D3 (PubChem CID: 5280795 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 457
Ref_1
Pair Name Neferine, Vitamin D3
Disease Info [ICD-11: 2B91.Z] Colorectal cancer Investigative
Biological Phenomena Inhibition-->Cell metastasis
Gene Regulation Up-regulation Expression CDH1 hsa999
Down-regulation Expression CDH2 hsa1000
Down-regulation Expression VIM hsa7431
Down-regulation Expression SNAI1 hsa6615
Down-regulation Expression SNAI2 hsa6591
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
Result These data suggest that neferine enhances the anticancer capability of VD3 and reduces the dose dependency of VD3. The combination of vitamin D with neferine appears to be a potential therapeutic strategy for CRC.
03. Reference
No. Title Href
1 Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer. J Cancer Res Clin Oncol. 2023 Aug;149(9):6203-6210. doi: 10.1007/s00432-022-04552-7. Click
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